Ehlers-Danlos syndrome (EDS) is a group of inherited disorders that affect your connective tissues — primarily your skin, joints and blood vessel walls. Connective tissue is a complex mixture of proteins and other substances that provide strength and elasticity to the underlying structures in your body.
People who have Ehlers-Danlos syndrome usually have overly flexible joints and stretchy, fragile skin. This can become a problem if you have a wound that requires stitches, because the skin often isn't strong enough to hold them. Many will experience wide wounds at the sites of injury or surgery.
A more severe form of the disorder, called Ehlers-Danlos syndrome, vascular type, can cause the walls of your blood vessels, intestines or uterus to rupture. Because Ehlers-Danlos syndrome, vascular type, can have serious potential complications in pregnancy, you willmay want to talk to a genetic counselor before starting a family.
Symptoms of Classic Ehlers-Danlos syndrome
Signs and symptoms of the most common form of Ehlers-Danlos syndrome include:
Overly flexible joints. Because the connective tissue that holds joints together is looser, your joints can move far past the normal range of motion. Joint pain and dislocations are common.
Stretchy skin. Weakened connective tissue allows your skin to stretch much more than usual. You may be able to pull a pinch of skin up away from your flesh, but it will snap right back into place when you let go. Your skin might also feel exceptionally soft and velvety.
Fragile skin. Damaged skin often doesn't heal well. For example, the stitches used to close a wound often will tear out and leave a gaping scar. These scars may look thin and crinkly.
Symptom severity can vary from person to person. Some people with Ehlers-Danlos syndrome will have overly flexible joints, but few or none of the skin symptoms. Some may have just a few joints affected while others may have many that are hypermobile and painful.
Ehlers-Danlos syndrome, vascular type
People who have Ehlers-Danlos syndrome, vascular type, often share distinctive facial features of a thin nose, thin upper lip, small earlobes and prominent eyes. They also have thin, translucent skin that bruises very easily. In fair-skinned people, the underlying blood vessels are very visible through the skin.
Ehlers-Danlos syndrome, vascular type, can weaken your heart's largest artery (aorta), as well as the arteries to other regions of your body. A rupture of any of these larger blood vessels can be fatal. The vascular type can also weaken the walls of the uterus or large intestines — which also may rupture.
Causes of Ehlers-Danlos Syndrome
Different types of Ehlers-Danlos syndrome are associated with a variety of genetic causes, some of which are inherited and passed on from parent to child. If you have the most common varieties of Ehlers-Danlos syndrome, there's a 50 percent chance that you'll pass on the gene to each of your children.
Complications of Ehlers-Danlos Syndrome
Complications depend on the types of signs and symptoms you have. For example, overly flexible joints can result in joint dislocations and early-onset arthritis. Fragile skin may develop prominent scarring.
People who have Ehlers-Danlos syndrome, vascular type, are at risk of often fatal ruptures of major blood vessels. Some organs, such as the uterus and intestines, also may rupture. Pregnancy can increase these risks.
Prevention of Ehlers-Danlos syndrome
If you have a personal or family history of Ehlers-Danlos syndrome and you're thinking about starting a family, you may benefit from talking to a genetic counselor — a health care professional trained to assess the risk of inherited disorders. Genetic counseling can help you understand the inheritance pattern of the type of Ehlers-Danlos syndrome that affects you and the risks it poses for your children.
Treatment of Joint Pain
People with EDS should avoid repetitive stress to the joints. It is important to keep the muscles strong to protect the joints but to not overexercise and allow adequate recovery time between exercise activities. If it joint has been stressed with exercise 72 hours of recovery time should be allowed before repeating exercise to the same area. Injections with prolotherapy or platelet rich plasma (PRP) can help stabilize and repair injured ligaments around painful joints. Patients with EDS may require a higher number or more frequent repeat injections than people without EDS. Even within the EDS population there can be a great deal of variability. It is also important to maintain a low inflammatory diet and have an adequate protein intake to help the body heal from daily wear and tear. EDS patient should avoid the regular use of anti-inflammatory medications and supplements. Although these will help the pain initially they also inhibit normal tissue repair.